Study
Creatine Supplementation and Resistance Training: A Comparison Between Novice and Experienced Lifters – A Systematic Review and Dose-Response Meta-Analysis
This comprehensive 2025 review found that creatine supplementation enhances muscle performance in both novice and experienced lifters, including ad...
Summary
In plain language
This comprehensive 2025 review found that creatine supplementation enhances muscle performance in both novice and experienced lifters, including adults over 60. Benefits included improved muscle mass, strength, and overall function when combined with resistance exercise. The study confirmed a strong safety profile and recommended creatine as a viable support for age-related muscle loss prevention.
Details
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This meta-analysis examined creatine supplementation combined with resistance training across age groups, including older adults. Results show significant improvements in muscle mass, strength, and function, particularly in untrained or sarcopenic individuals. No major adverse effects were reported with daily doses up to 5 grams.
Full Study
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Creatine Supplementation and Resistance Training: A Comparison Between Novice and Experienced Lifters – A Systematic Review and Dose-Response Meta-Analysis
Published December 2025
Opens at the publisher · external site · may require institutional access
Research Quality Score
Scored January 20, 2026 using rubric v5_2025-02-01.
Assessment
The study is a well-conducted systematic review and meta-analysis that provides valuable insights into the effects of creatine supplementation on muscle performance. It is methodologically sound but could improve in areas such as bias control and transparency. Overall, it contributes meaningfully to the existing literature.
Category Breakdown
| Category | Score | Rating |
|---|---|---|
| Study design | 8.3/10 | |
| Bias control | 6.7/10 | |
| Statistical methods | 7.5/10 | |
| Reporting completeness | 7.5/10 | |
| Conflicts & funding | 10.0/10 | |
| Replication | 5.0/10 | |
| Relevance to chosen population | 10.0/10 | |
| Journal Reliability | 7.5/10 |
Additional Notes
The study could benefit from more detailed reporting on the heterogeneity of included studies and potential publication bias. Future research should focus on long-term effects and different dosing strategies.
Treatments Evaluated in This Research
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Strength Training
Strength training involves exercises that improve muscle strength and endurance. It is beneficial for seniors, helping to maintain muscle mass, improve balance, and enhance overall quality of life. This form of exercise can be adapted to various fitness levels, making it accessible for older adults.
Creatine
Creatine is a compound that helps the body produce energy in muscles and the brain. It supports strength, endurance, and cognitive performance, making it valuable for older adults seeking to maintain vitality.
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