Study
Feasibility of Aspirin and/or Vitamin D3 for Men with Prostate Cancer on Active Surveillance with Prolaris® Testing
Early-phase study suggesting aspirin is safe and feasible for men with low-risk prostate cancer under monitoring.
Men's Health
Summary
In plain language
Early-phase study suggesting aspirin is safe and feasible for men with low-risk prostate cancer under monitoring. While biologically plausible, larger trials are needed to determine if it slows disease progression.
Details
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This feasibility study examined whether low-dose aspirin and/or vitamin D3 could be safely used in men with prostate cancer under active surveillance. The intervention was well-tolerated, with good adherence and no serious safety concerns.
Full Study
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Feasibility of Aspirin and/or Vitamin D3 for Men with Prostate Cancer on Active Surveillance with Prolaris® Testing
Published December 2025
Opens at the publisher · external site · may require institutional access
Research Quality Score
Assessment
The study provides initial feasibility data on the use of aspirin and vitamin D3 in older adults with prostate cancer. While it is relevant and published in a reputable journal, the study design lacks the rigor of later-phase trials, and there is limited bias control and replication data.
Category Breakdown
| Category | Score | Rating |
|---|---|---|
| Study Design / Evidence Level | 6.0/10 | |
| Bias & Methods | 5.0/10 | |
| Statistical Integrity | 6.0/10 | |
| Transparency | 7.0/10 | |
| Conflict of Interest Disclosure | 8.0/10 | |
| Replication / External Validation | 4.0/10 | |
| Relevance to Seniors | 9.0/10 | |
| Journal Quality | 7.0/10 |
Additional Notes
The study is a preliminary investigation, and its findings should be interpreted with caution. Larger, more rigorous trials are necessary to confirm these initial findings.
Treatments Evaluated in This Research
Review the interventions studied here and compare them against the broader treatment library.
Treatment Option
Vitamin K2 + D3 Complex
This combination pairs vitamin D3 with vitamin K2 to optimize calcium metabolism. D3 enhances calcium absorption while K2 directs that calcium to bones and teeth, preventing unwanted deposition in soft tissues.
3 studies
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Treatment Option
Vitamin D3
Vitamin D3 (cholecalciferol) is the most bioactive form of vitamin D, essential for calcium absorption, immune function, and mood regulation. It's produced naturally through sun exposure but many people require supplementation.
2 studies
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