Study
Melatonin May Reduce Migraine Frequency in Adults
Research suggests melatonin supplementation could help decrease the frequency and severity of migraines in adults.
Summary
In plain language
Recent research highlights that taking melatonin, a natural hormone that regulates sleep, might help reduce migraine frequency and severity in adults. The study reviewed various trials where melatonin was compared to other treatments and a placebo. Findings indicate that melatonin can be an effective and safe option for preventing migraines. This is particularly relevant for seniors who experience migraines and are looking for new prevention methods. However, it’s always wise to consult with a healthcare provider before starting any new supplement.
Details
Use the full description to understand the study design, methods, and the limits of the findings.
The study combined results from nine different trials to understand melatonin's effect on migraines.
Researchers found that melatonin, particularly in doses ranging from 2 mg to 6 mg, could reduce the frequency and intensity of migraine attacks.
While the study showed promising results, it noted that the number of participants and studies was limited, suggesting a need for more research.
For seniors, adding melatonin could be an easy, natural way to manage migraines, but it’s important to discuss any new supplement with a healthcare provider to ensure it’s right for you.
Remember, always consult with your doctor before starting new treatments.
Full Study
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Melatonin May Reduce Migraine Frequency in Adults
Published January 2026
Opens at the publisher · external site · may require institutional access
Research Quality Score
Scored October 22, 2026 using rubric mq-1.8_2026-07-06.
Assessment
The study scored well in study design and transparency due to its rigorous meta-analytic approach and adherence to PRISMA guidelines. Bias control was moderate as not all included studies had low risk of bias. Statistical integrity was strong with appropriate methods and reporting. However, conflicts of interest were significant due to industry ties, and journal quality could not be assessed. Relevance was partial due to mixed-age populations, and replication was limited to consistency with prior findings.
Category Breakdown
| Category | Score | Rating |
|---|---|---|
| Study design | 10.0/10 | |
| Bias control | 6.7/10 | |
| Statistical methods | 10.0/10 | |
| Reporting completeness | 10.0/10 | |
| Conflicts & funding | 5.0/10 | |
| Replication | 5.0/10 | |
| Relevance to chosen population | 5.0/10 | |
| Journal Reliability | 5.0/10 |
Additional Notes
This meta-analysis evaluates the efficacy and safety of melatonin for migraine prophylaxis, comparing it with placebo and amitriptyline. It includes nine RCTs and reports significant reductions in migraine frequency and severity with melatonin compared to placebo.
Assessed on the study's full text across 8 quality dimensions; conflict-of-interest disclosures were reviewed.
Conditions This Research Covers
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Treatments Evaluated in This Research
Review the interventions studied here and compare them against the broader treatment library.
Melatonin
Melatonin is a hormone that regulates the sleep–wake cycle. Supplemental melatonin supports better sleep quality and helps older adults maintain consistent rest patterns.
Melatonin Complex (with L-Theanine + Magnesium)
This combination of melatonin, L-theanine, and magnesium promotes relaxation, stress relief, and high-quality restorative sleep.
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