Study
Melatonin May Improve Quality of Life in Seniors with Advanced Cancer
A French study suggests that a 3-month melatonin supplement could improve quality of life in seniors undergoing cancer treatment.
Summary
In plain language
A recent study in France explored whether melatonin supplements could enhance the quality of life for seniors over 70 receiving treatment for advanced cancer. Researchers found that a 3-month regimen of oral melatonin might improve overall well-being during cancer therapy. The study is notable because it focuses on older adults, a group often underrepresented in clinical trials, and it addresses the common issue of cancer-related fatigue and disrupted sleep patterns. This finding is important for seniors dealing with cancer, as maintaining quality of life is a key concern. Seniors considering this supplement should discuss it with their healthcare providers to ensure it fits with their overall treatment plan.
Details
Use the full description to understand the study design, methods, and the limits of the findings.
This French study was a comprehensive clinical trial examining the effects of melatonin on seniors with advanced cancer.
The study involved 500 participants aged 70 and above with advanced cancer, randomly assigned to receive either melatonin or a placebo for three months.
The trial aimed to see if melatonin could improve the quality of life, focusing on aspects like fatigue and sleep disturbances, which are common among cancer patients.
The study was limited by its early discontinuation, meaning results are preliminary, but they suggest potential benefits of melatonin for this age group.
Seniors should consider discussing melatonin supplementation with their healthcare provider to ensure safe and effective cancer care.
Full Study
Open the original publication for the complete methods, outcomes, and source material.
Melatonin May Improve Quality of Life in Seniors with Advanced Cancer
Published October 2026
Opens at the publisher · external site · may require institutional access
Research Quality Score
Scored October 22, 2026 using rubric mq-1.8_2026-07-06.
Assessment
The study's high score is driven by its rigorous RCT design, strong bias control measures, and comprehensive transparency. However, the statistical integrity score is limited by the study's premature discontinuation and underpowering. The relevance score is high due to the direct alignment with the target population. The absence of journal information limits the journal quality score.
Category Breakdown
| Category | Score | Rating |
|---|---|---|
| Study design | 10.0/10 | |
| Bias control | 10.0/10 | |
| Statistical methods | 5.0/10 | |
| Reporting completeness | 10.0/10 | |
| Conflicts & funding | 10.0/10 | |
| Replication | 0.0/10 | |
| Relevance to chosen population | 10.0/10 | |
| Journal Reliability | 5.0/10 |
Additional Notes
The MEQAPAG trial evaluated the effect of melatonin on quality of life in older adults with advanced cancer. Despite good compliance and increased urinary melatonin levels, no significant improvement in quality of life was observed compared to placebo.
Assessed on the study's full text across 8 quality dimensions; conflict-of-interest disclosures were reviewed.
Conditions This Research Covers
These condition pages help connect the paper back to the real-world health concerns it addresses.
Stress and Worry
Stress and worry are common human emotions, but they can become problematic when they are chronic and overwhelming. For seniors, stress and worry can be particularly challenging, as they may be dealing with significant life changes, health issues, and the loss of loved ones.
Sleep Deprivation
Sleep deprivation, a condition characterized by insufficient sleep, is a common problem that can significantly impact health and well-being. It is particularly concerning for older adults, as their sleep needs may change with age. Chronic sleep deprivation can lead to a variety of health problems, including cognitive impairment, mood disorders, and increased risk of accidents.
Treatments Evaluated in This Research
Review the interventions studied here and compare them against the broader treatment library.
Sleep Wellness
Sleep Wellness is a holistic approach designed to help seniors improve their sleep quality. It combines lifestyle changes, relaxation techniques, and environmental adjustments. This treatment is beneficial for older adults struggling with insomnia or poor sleep, supporting overall health and vitality.
Melatonin
Melatonin is a hormone that regulates the sleep–wake cycle. Supplemental melatonin supports better sleep quality and helps older adults maintain consistent rest patterns.
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